Journal Article

Blood Pressure in Relation to Birth Weight in Twins and Singleton Controls Matched for Gestational Age

Geraldine McNeill, Chuluuntulga Tuya, Doris M. Campbell, Paul Haggarty, W. Cairns S. Smith, Lindsey F. Masson, Alastair Cumming, Ian Broom and Neva Haites

in American Journal of Epidemiology

Published on behalf of Johns Hopkins Bloomberg School of Public Health

Volume 158, issue 2, pages 150-155
Published in print July 2003 | ISSN: 0002-9262
Published online July 2003 | e-ISSN: 1476-6256 | DOI: http://dx.doi.org/10.1093/aje/kwg130
Blood Pressure in Relation to Birth Weight in Twins and Singleton Controls Matched for Gestational Age

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Associations between adult blood pressure and birth weight were investigated in 122 same-sex twin pairs aged 18–50 years and 86 singleton controls matched according to maternal age and parity, gender, gestational age, and current age who were recruited via an obstetric database in Aberdeen, Scotland, in 1999. Twins weighed on average 425 g less than controls at birth (p < 0.001) but did not differ significantly in adult height or systolic or diastolic blood pressure from the controls. Among controls, the differences in systolic and diastolic blood pressure per kg of difference in birth weight, adjusted for gender, gestational age, current age, body mass index, smoking, physical activity level, and alcohol intake, were –4.3 (95% confidence interval (CI): –12.8, 4.3) and –6.1 (95% CI: –10.8, –1.5) mmHg/kg, respectively. In unpaired analysis among all twins, the equivalent values were –0.1 (95% CI: –4.0, 3.8) mmHg/kg for systolic pressure and –0.4 (95% CI: –2.9, 2.2) mmHg/kg for diastolic pressure, while in within-pair analysis the values were –0.9 (95% CI: –6.4, 4.6) mmHg/kg for systolic pressure and –0.2 (95% CI: –4.1, 3.7) mmHg/kg for diastolic pressure. The results suggest that in-utero growth restriction in twins is not a major determinant of their blood pressure as adults.

Keywords: birth weight; blood pressure; twins

Journal Article.  4472 words. 

Subjects: Public Health and Epidemiology

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