Journal Article

Selection Bias in the Assessment of Gene-Environment Interaction in Case-Control Studies

Libby M. Morimoto, Emily White and Polly A. Newcomb

in American Journal of Epidemiology

Published on behalf of Johns Hopkins Bloomberg School of Public Health

Volume 158, issue 3, pages 259-263
Published in print August 2003 | ISSN: 0002-9262
Published online August 2003 | e-ISSN: 1476-6256 | DOI: http://dx.doi.org/10.1093/aje/kwg147
Selection Bias in the Assessment of Gene-Environment Interaction in Case-Control Studies

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Selection bias is a common concern in epidemiologic studies, particularly case-control studies. Selection bias in the odds ratio occurs when participation depends jointly on exposure and disease status. General results for understanding when selection bias may affect studies involving gene-environment interactions have not yet been developed. In this paper, the authors show that the assessment of gene-environment interactions will not be subject to selection bias under the assumption that genotype does not influence participation conditional on exposure and disease status. This is true even when selection, including self-selection of subjects, is jointly influenced by exposure and disease and regardless of whether the genotype is related to exposure, disease, or both. The authors present an example to illustrate this concept.

Keywords: bias (epidemiology); case-control studies; environment; epidemiologic methods; genotype; polymorphism (genetics); risk factors; selection bias

Journal Article.  2916 words.  Illustrated.

Subjects: Public Health and Epidemiology

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