Journal Article

Serum Insulin-like Growth Factor I and Subsequent Risk of Colorectal Cancer among Japanese-American Men

Abraham M. Y. Nomura, Grant N. Stemmermann, James Lee and Michael N. Pollak

in American Journal of Epidemiology

Published on behalf of Johns Hopkins Bloomberg School of Public Health

Volume 158, issue 5, pages 424-431
Published in print September 2003 | ISSN: 0002-9262
Published online September 2003 | e-ISSN: 1476-6256 | DOI: http://dx.doi.org/10.1093/aje/kwg176
Serum Insulin-like Growth Factor I and Subsequent Risk of Colorectal Cancer among Japanese-American Men

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Recent reports suggest that colorectal cancer is positively related to insulin-like growth factor I (IGF-I) and inversely related to insulin-like growth factor binding protein 3 (IGFBP-3). To evaluate these associations further and separately for colon and rectal cancer, the authors conducted a nested case-control study in a cohort of 9,345 Japanese-American men examined in Hawaii in 1971–1977. A total of 177 incident colon cancer cases and 105 incident rectal cancer cases were identified from 1972 to 1996. These patients’ stored sera and those of 282 age-matched controls were measured for IGF-I and IGFBP-3. The adjusted mean level of IGF-I was higher in colon cancer cases than in controls (154.7 ng/ml vs. 144.4 ng/ml; p = 0.01). However, the multivariate odds ratio for the highest quartile compared with the lowest was just 1.8 (95% confidence interval: 0.8, 4.3). Adjusted mean IGF-I levels were similar between rectal cancer cases and their controls. For IGFBP-3, adjusted mean levels were lower for both colon and rectal cancer cases than for their matched controls, but the differences were not significant. The IGF-I results weakly support findings from other studies and suggest that there are differences in IGF-I findings between colon and rectal cancer cases. It is possible that IGF-related risk is confounded by other factors that may vary among different cohorts. Further research is needed to clarify these relations.

Keywords: colonic neoplasms; colorectal neoplasms; insulin-like growth factor I; insulin-like growth factor binding protein 3; rectal neoplasms; Abbreviations: IGF, insulin-like growth factor; IGFBP, insulin-like growth factor binding protein.

Journal Article.  5646 words. 

Subjects: Public Health and Epidemiology

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