Journal Article

Flexible Matching in Case-Control Studies of Gene-Environment Interactions

Catherine L. Saunders and Jennifer H. Barrett

in American Journal of Epidemiology

Published on behalf of Johns Hopkins Bloomberg School of Public Health

Volume 159, issue 1, pages 17-22
Published in print January 2004 | ISSN: 0002-9262
Published online January 2004 | e-ISSN: 1476-6256 | DOI:
Flexible Matching in Case-Control Studies of Gene-Environment Interactions

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Because of the lack of power of case-control study designs to detect gene-environment interactions, flexible matching has recently been proposed as a method of improving efficiency. In this paper, the authors consider a large-sample approximation method that allows estimation of the most efficient matching strategy when genotype and exposure are either independent or associated. The authors provide tables of the sample sizes required to detect gene-environment interactions if this flexible matching strategy is followed, and they make brief comparisons with other study designs.

Keywords: case-control studies; epidemiologic methods; interaction; research design; statistics

Journal Article.  3872 words. 

Subjects: Public Health and Epidemiology

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