Journal Article

Weight Loss: A Determinant of Hip Bone Loss in Older Men and Women

James D. Knoke and Elizabeth Barrett-Connor

in American Journal of Epidemiology

Published on behalf of Johns Hopkins Bloomberg School of Public Health

Volume 158, issue 12, pages 1132-1138
Published in print December 2003 | ISSN: 0002-9262
Published online December 2003 | e-ISSN: 1476-6256 | DOI:
Weight Loss: A Determinant of Hip Bone Loss in Older Men and Women

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The sex-specific effect of weight change on change in total hip bone mineral density was evaluated over 4 years (1992–1996) in 1,214 community-dwelling adults whose mean age at baseline was 71 years. Weight and bone mineral density (by dual-energy x-ray absorptiometry) were assessed at two study visits. The average bone loss was 0.5% per year in both sexes; 29% of men and 28% of women lost at least 1% of bone mineral density per year. More than one in five participants lost at least 1% of their body weight per year (21% of men and 23% of women). These weight losers were twice as likely as others to lose bone at the rate of at least 1% per year. In analyses controlling for age, baseline weight, and lifestyle, weight loss was the strongest independent predictor of bone loss (odds ratios were 1.53 for men and 1.56 for women). Persons with weight loss of at least 1% per year were more likely to report fair or poor health and functional limitation at the second visit and to die within 2 years of the second visit; however, most did not report declining health, and most survived for at least 2 additional years.

Keywords: aged; bone density; osteoporosis; prospective studies; weight loss; Abbreviation: BMD, bone mineral density.

Journal Article.  4730 words. 

Subjects: Public Health and Epidemiology

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