Journal Article

Association between Gestational Diabetes and Pregnancy-induced Hypertension

Chris L. Bryson, George N. Ioannou, Stephen J. Rulyak and Cathy Critchlow

in American Journal of Epidemiology

Published on behalf of Johns Hopkins Bloomberg School of Public Health

Volume 158, issue 12, pages 1148-1153
Published in print December 2003 | ISSN: 0002-9262
Published online December 2003 | e-ISSN: 1476-6256 | DOI:
Association between Gestational Diabetes and Pregnancy-induced Hypertension

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Gestational diabetes and pregnancy-induced hypertension are common, and their relation is not well understood. The authors conducted a population-based case-control study using 1992–1998 Washington State birth certificate and hospital discharge records to investigate this relation. Consecutive cases of pregnancy-induced hypertension were divided into four groups based on International Classification of Diseases, Ninth Revision codes: eclampsia (n = 154), severe preeclampsia (n = 1,180), mild preeclampsia (n = 5,468), and gestational hypertension (n = 8,943). Cases were compared with controls who did not have pregnancy-induced hypertension (n = 47,237). Gestational diabetes was more common in each case group (3.9% in eclamptics, 4.5% in severe preeclamptics, and 4.4% in both mild preeclamptics and those with gestational hypertension) than in controls (2.7%). After adjustment for body mass index, age, ethnicity, parity, and prenatal care, gestational diabetes was associated with increased risk of severe preeclampsia (odds ratio (OR) = 1.5, 95% confidence interval (CI): 1.1, 2.1), mild preeclampsia (OR = 1.5, 95% CI: 1.3, 1.8), and gestational hypertension (OR = 1.4, 95% CI: 1.2, 1.6). Gestational diabetes was more strongly associated with pregnancy-induced hypertension among women who received less prenatal care (OR = 4.2 for eclampsia and OR = 3.1 for severe preeclampsia, p < 0.05 for both) and among Black women (OR for eclampsia and preeclampsia together = 3.9, p < 0.05).

Keywords: diabetes, gestational; eclampsia; ethnic groups; hypertension; pre-eclampsia; pregnancy complications; pregnancy complications, cardiovascular; prenatal care; Abbreviations: CI, confidence interval; ICD-9, International Classification of Diseases, Ninth Revision; OR, odds ratio.

Journal Article.  3857 words. 

Subjects: Public Health and Epidemiology

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