Journal Article

Is Obesity Associated with Major Depression? Results from the Third National Health and Nutrition Examination Survey

Chiadi U. Onyike, Rosa M. Crum, Hochang B. Lee, Constantine G. Lyketsos and William W. Eaton

in American Journal of Epidemiology

Published on behalf of Johns Hopkins Bloomberg School of Public Health

Volume 158, issue 12, pages 1139-1147
Published in print December 2003 | ISSN: 0002-9262
Published online December 2003 | e-ISSN: 1476-6256 | DOI: http://dx.doi.org/10.1093/aje/kwg275
Is Obesity Associated with Major Depression? Results from the Third National Health and Nutrition Examination Survey

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Data from the Third National Health and Nutrition Examination Survey (1988–1994) were used to examine the relation between obesity and depression. Past-month depression was defined using criteria from the Diagnostic and Statistical Manual of Mental Disorders, Third Edition, and was measured with the Diagnostic Interview Schedule. Obesity was defined as a body mass index (weight (kg)/height (m)2) of 30 or higher. The authors compared risks of depression in obese and normal-weight (body mass index 18.5–24.9) persons. Obesity was associated with past-month depression in women (odds ratio (OR) = 1.82, 95% confidence interval (CI): 1.01, 3.3) but was not significantly associated in men (OR = 1.73, 95% CI: 0.56, 5.37). When obesity was stratified by severity, heterogeneity in the association with depression was observed. Class 3 (severe) obesity (body mass index ≥40) was associated with past-month depression in unadjusted analyses (OR = 4.98, 95% CI: 2.07, 11.99); the association remained strong after results were controlled for age, education, marital status, physician’s health rating, dieting for medical reasons, use of psychiatric medicines, cigarette smoking, and use of alcohol, marijuana, and cocaine. These findings suggest that obesity is associated with depression mainly among persons with severe obesity. Prospective studies will be necessary to clarify the obesity-depression relation but await the identification of potential risk factors for depression in the obese.

Keywords: body mass index; body weight; depression; obesity; Abbreviations: BMI, body mass index; CI, confidence interval; DIS, Diagnostic Interview Schedule; DSM, Diagnostic and Statistical Manual of Mental Disorders; NHANES III, Third National Health and Nutritional Examination Survey; OR, odds ratio.

Journal Article.  6752 words. 

Subjects: Public Health and Epidemiology

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