Journal Article

Alcohol Intake, Drinking Patterns, and Risk of Prostate Cancer in a Large Prospective Cohort Study

Elizabeth A. Platz, Michael F. Leitzmann, Eric B. Rimm, Walter C. Willett and Edward Giovannucci

in American Journal of Epidemiology

Published on behalf of Johns Hopkins Bloomberg School of Public Health

Volume 159, issue 5, pages 444-453
Published in print March 2004 | ISSN: 0002-9262
Published online March 2004 | e-ISSN: 1476-6256 | DOI:
Alcohol Intake, Drinking Patterns, and Risk of Prostate Cancer in a Large Prospective Cohort Study

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Alcohol drinking has been extensively studied in relation to prostate cancer, yet findings on the direction of the association are equivocal. Previous studies have not examined drinking patterns. Thus, the authors prospectively evaluated the associations between these factors and risk of incident prostate cancer (n = 2,479) in a cohort study of 47,843 US men (1986–1998). The men completed a questionnaire at baseline that included information on consumption of specific types of alcohol and frequency of use. The authors estimated hazard ratios using Cox proportional hazards regression for average alcohol intake and number of days per week on which alcohol was consumed stratified by average weekly intake (<105 g/week vs. ≥105 g/week). Compared with nondrinking, the hazard ratio for consumption increased slightly from an average of 5.0–14.9 g/day (hazard ratio (HR) = 1.05, 95% confidence interval (CI): 0.94, 1.18) to 30.0–49.9 g/day (HR = 1.13, 95% CI: 0.96, 1.33), but it was not increased at ≥50 g/day (HR = 1.00, 95% CI: 0.77, 1.31) after adjustment for recent smoking and other factors. Compared with abstainers, risk was greatest among men who consumed an average of ≥105 g/week but who drank on only 1–2 days per week (HR = 1.64, 95% CI: 1.13, 2.38). These results suggest that moderate or greater alcohol consumption is not a strong contributor to prostate cancer risk, except possibly in men who consume large amounts infrequently.

Keywords: alcohol drinking; cohort studies; ethanol; prostatic neoplasms; risk; Abbreviations: CI, confidence interval; HR, hazard ratio.

Journal Article.  7030 words.  Illustrated.

Subjects: Public Health and Epidemiology

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