Journal Article

A Case-Control Study of Serum Tocopherol Levels and the Alpha- to Gamma-Tocopherol Ratio in Radiographic Knee Osteoarthritis

Joanne M. Jordan, Anneclaire J. De Roos, Jordan B. Renner, Gheorghe Luta, Amy Cohen, Neal Craft, Charles G. Helmick, Marc C. Hochberg and Lenore Arab

in American Journal of Epidemiology

Published on behalf of Johns Hopkins Bloomberg School of Public Health

Volume 159, issue 10, pages 968-977
Published in print May 2004 | ISSN: 0002-9262
Published online May 2004 | e-ISSN: 1476-6256 | DOI: http://dx.doi.org/10.1093/aje/kwh133
A Case-Control Study of Serum Tocopherol Levels and the Alpha- to Gamma-Tocopherol Ratio in Radiographic Knee Osteoarthritis

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Tocopherols are lipid-soluble antioxidants that may protect against some conditions of aging. The authors examined associations between radiographic knee osteoarthritis and serum levels of α-, δ-, and γ-tocopherol and the α:γ-tocopherol ratio in African-American and White adults from the Johnston County Osteoarthritis Project (North Carolina, 1991–1997). Two hundred cases with radiographic knee osteoarthritis (Kellgren-Lawrence grades ≥2) and 200 controls (Kellgren-Lawrence grade 0) were randomly selected and matched by age, ethnicity, and sex. Serum tocopherol levels were measured by high performance liquid chromatography. Conditional logistic regression was used to estimate associations between radiographic knee osteoarthritis and tertiles of each tocopherol measure, independent of confounders. Persons in the highest tertile of the α:γ-tocopherol ratio had half the odds of radiographic knee osteoarthritis as those in the lowest tertile (adjusted odds ratio = 0.5, 95% confidence interval: 0.2, 1.2). This inverse association occurred in all ethnic and sex subgroups, significantly in African Americans and men. Radiographic knee osteoarthritis was inversely associated with serum α-tocopherol in African Americans and men, positively associated with serum γ-tocopherol in men, and unassociated with serum δ-tocopherol. Associations between radiographic knee osteoarthritis and tocopherol isoforms are complex and may vary by ethnicity and sex.

Keywords: alpha-tocopherol; antioxidants; gamma-tocopherol; osteoarthritis, knee; tocopherols; vitamin E; Abbreviation: HPLC, high performance liquid chromatography.

Journal Article.  7114 words. 

Subjects: Public Health and Epidemiology

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