Journal Article

Risk Factors for Enteric Perforation in Patients with Typhoid Fever

Salih Hosoglu, Mustafa Aldemir, Serife Akalin, Mehmet Faruk Geyik, Ibrahim H. Tacyildiz and Mark Loeb

in American Journal of Epidemiology

Published on behalf of Johns Hopkins Bloomberg School of Public Health

Volume 160, issue 1, pages 46-50
Published in print July 2004 | ISSN: 0002-9262
Published online July 2004 | e-ISSN: 1476-6256 | DOI:
Risk Factors for Enteric Perforation in Patients with Typhoid Fever

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A case-control study was performed using the records of patients hospitalized for typhoid fever at Dicle University Hospital, Diyarbakir, Turkey, between 1994 and 1998. Case patients with enteric perforation were compared with control patients with typhoid fever but no enteric perforation. Risk factors for perforation were determined using logistic regression modeling. Forty case patients who had surgery because of typhoid enteric perforation were compared with 80 control patients. In univariate analyses, male sex (p = 0.01), age (p = 0.01), leukopenia (p = 0.01), inadequate antimicrobial therapy prior to admission (p = 0.01), and short duration of symptoms (p = 0.01) were significantly associated with perforation. In multivariate analysis, male sex (odds ratio (OR) = 4.39, 95% confidence interval (CI): 1.37, 14.09; p = 0.01), leukopenia (OR = 3.88, 95% CI: 1.46, 10.33; p = 0.04), inadequate treatment prior to admission (OR = 4.58, 95% CI: 1.14, 18.35; p = 0.03), and short duration of symptoms (OR = 1.22, 95% CI: 1.10, 1.35; p = 0.001) were significant predictors of perforation. A short duration of symptoms, inadequate antimicrobial therapy, male sex, and leukopenia are independent risk factors for enteric perforation in patients with typhoid fever.

Keywords: intestinal perforation; multivariate analysis; risk factors; typhoid fever; Abbreviations: CI, confidence interval; OR, odds ratio.

Journal Article.  3294 words. 

Subjects: Public Health and Epidemiology

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