Journal Article

Incidence of Laparoscopically Confirmed Endometriosis by Demographic, Anthropometric, and Lifestyle Factors

Stacey A. Missmer, Susan E. Hankinson, Donna Spiegelman, Robert L. Barbieri, Lynn M. Marshall and David J. Hunter

in American Journal of Epidemiology

Published on behalf of Johns Hopkins Bloomberg School of Public Health

Volume 160, issue 8, pages 784-796
Published in print October 2004 | ISSN: 0002-9262
Published online October 2004 | e-ISSN: 1476-6256 | DOI: http://dx.doi.org/10.1093/aje/kwh275
Incidence of Laparoscopically Confirmed Endometriosis by Demographic, Anthropometric, and Lifestyle Factors

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The authors investigated the relations of demographic, anthropometric, and lifestyle factors with endometriosis in the Nurses’ Health Study II prospective cohort. During 10 years of follow-up (1989–1999), 1,721 cases of laparoscopically confirmed endometriosis were reported among women with no past infertility. The incidence rate was greatest among women aged 25–29 years and lowest among women over 44 years (ptrend < 0.0001). In multivariate Cox proportional hazards models, African-American women had a lower rate of disease compared with Caucasian women (rate ratio = 0.6, 95% confidence interval: 0.4, 0.9). The authors also observed an inverse relation with body mass index at age 18 years (for body mass index of >30 vs. 19–20.4 kg/m2: rate ratio = 0.8, 95% confidence interval: 0.6, 1.1; ptrend = 0.004) and with current alcohol intake (for >10 vs. 0 g/day: rate ratio = 0.7, 95% confidence interval: 0.6, 0.8; ptrend < 0.0001) but no association with height, waist/hip ratio, or caffeine intake. An inverse relation with current body mass index and current cigarette smoking was observed only when cases were concurrently infertile. The authors conclude that age, race, body mass index, alcohol use, and cigarette smoking are associated with the incidence of endometriosis and that some of these relations may differ by infertility status at the time of laparoscopic diagnosis.

Keywords: alcohol drinking; anthropometry; cohort studies; continental population groups; endometriosis; incidence; prevalence

Journal Article.  7174 words.  Illustrated.

Subjects: Public Health and Epidemiology

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