Journal Article

Dietary Patterns and Colorectal Adenomas in Japanese Men

Tetsuya Mizoue, Taiki Yamaji, Shinji Tabata, Keizo Yamaguchi, Eiichi Shimizu, Masamichi Mineshita, Shinsaku Ogawa and Suminori Kono

in American Journal of Epidemiology

Published on behalf of Johns Hopkins Bloomberg School of Public Health

Volume 161, issue 4, pages 338-345
Published in print February 2005 | ISSN: 0002-9262
Published online February 2005 | e-ISSN: 1476-6256 | DOI:
Dietary Patterns and Colorectal Adenomas in Japanese Men

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The role of dietary patterns in colorectal carcinogenesis remains unclear in Asian populations. Using 1999–2002 data, the authors investigated the association between dietary patterns and colorectal adenomas in 1,341 Japanese men who underwent total colonoscopy. Information about diet was obtained using a 74-item food frequency questionnaire prior to the colonoscopy. Three dietary patterns were generated by factor analysis: 1) a high-dairy, high-fruit and -vegetable, high-starch, low-alcohol pattern; 2) an “animal food” pattern; and 3) a Japanese pattern. Logistic regression analysis was used to estimate the odds ratio of having colorectal adenomas with the adjustment for potential confounding variables including body mass index, smoking, alcohol, and leisure-time physical activities. A significant inverse association was found for the high-dairy, high-fruit and -vegetable, high-starch, low-alcohol pattern; the odds ratios for the second, third, and fourth quartiles were 0.97 (95% confidence interval: 0.70, 1.36), 0.71 (95% confidence interval: 0.50, 1.01), and 0.62 (95% confidence interval: 0.43, 0.90), respectively, compared with the lowest (ptrend = 0.003). Similar associations were observed for larger adenomas or for each subsite of the colorectum. The Japanese and “animal food” patterns were not clearly associated with colorectal adenomas. A dietary pattern including greater consumption of dairy products and fruits and vegetables with low alcohol consumption may be associated with decreased risk of colorectal adenomas.

Keywords: adenoma; cross-sectional studies; diet; DFSA, high-dairy, high-fruit and -vegetable, high-starch, low-alcohol (dietary pattern).

Journal Article.  6022 words. 

Subjects: Public Health and Epidemiology

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