Journal Article

Serum Levels of Polyunsaturated Fatty Acids and Risk of Colorectal Cancer: A Prospective Study

Masayo Kojima, Kenji Wakai, Shinkan Tokudome, Koji Suzuki, Koji Tamakoshi, Yoshiyuki Watanabe, Miyuki Kawado, Shuji Hashimoto, Norihiko Hayakawa, Kotaro Ozasa, Hideaki Toyoshima, Sadao Suzuki, Yoshinori Ito and Akiko Tamakoshi

in American Journal of Epidemiology

Published on behalf of Johns Hopkins Bloomberg School of Public Health

Volume 161, issue 5, pages 462-471
Published in print March 2005 | ISSN: 0002-9262
Published online March 2005 | e-ISSN: 1476-6256 | DOI: http://dx.doi.org/10.1093/aje/kwi066
Serum Levels of Polyunsaturated Fatty Acids and Risk of Colorectal Cancer: A Prospective Study

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To examine the relation between serum fatty acids and risk of colorectal cancer, the authors conducted a nested case-control study of 169 colorectal cancer cases and 481 controls matched by age and enrollment area as part of the Japan Collaborative Cohort Study. Serum samples were donated by subjects at baseline (between 1988 and 1990) and were stored at –80°C until 2002. Serum fatty acid levels were measured by using gas chromatography and were expressed as the weight percentage of total lipids. Conditional logistic regression analyses adjusted for lifestyle factors revealed that total ω-3 polyunsaturated fatty acids (odds ratio = 0.24, 95% confidence interval: 0.08, 0.76), α-linolenic acid (odds ratio = 0.39, 95% confidence interval: 0.16, 0.91), docosapentaenoic acid (odds ratio = 0.30, 95% confidence interval: 0.11, 0.80), and docosahexaenoic acid (odds ratio = 0.23, 95% confidence interval: 0.07, 0.76) all showed a significantly decreased risk for the highest versus the lowest quartile levels for colorectal cancer in men. For women, a weak negative association was observed between docosapentaenoic acid and colorectal cancer risk, although it was not statistically significant. No adverse effects of high serum levels of ω-6 polyunsaturated fatty acids on colorectal cancer risk were detected.

Keywords: alpha-linolenic acid; chromatography; colorectal neoplasms; docosahexaenoic acids; eicosapentaenoic acid; fatty acids; prospective studies; serum; CI, confidence interval; JACC Study, Japan Collaborative Cohort Study for the Evaluation of Cancer Risk; MUFA, monounsaturated fatty acids; PUFA, polyunsaturated fatty acid; Q, quartile.

Journal Article.  6868 words. 

Subjects: Public Health and Epidemiology

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