Journal Article

Influence of Paternal Age on the Risk of Spontaneous Abortion

Rémy Slama, Jean Bouyer, Gayle Windham, Laura Fenster, Axel Werwatz and Shanna H. Swan

in American Journal of Epidemiology

Published on behalf of Johns Hopkins Bloomberg School of Public Health

Volume 161, issue 9, pages 816-823
Published in print May 2005 | ISSN: 0002-9262
Published online May 2005 | e-ISSN: 1476-6256 | DOI: http://dx.doi.org/10.1093/aje/kwi097
Influence of Paternal Age on the Risk of Spontaneous Abortion

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The frequency of chromosomal anomalies in spermatozoa appears to increase with male age. Because these anomalies play a role in the etiology of spontaneous abortion, an influence of paternal age on risk of spontaneous abortion is plausible but not established. The aim was to characterize this influence in a prospective study among 5,121 California women, who as members of a prepaid health plan were interviewed in 1990 or 1991 when they were less than 13 weeks' pregnant and who were followed until the end of pregnancy. The risk of spontaneous abortion between weeks 6 and 20 of pregnancy was studied using a Cox model adjusted for maternal age. The adjusted hazard ratio of spontaneous abortion associated with paternal age of 35 years or more, compared with less than 35 years, was 1.27 (95% confidence interval: 1.00, 1.61), with no modification by maternal age. Among women aged less than 30 years, the hazard ratio of spontaneous abortion associated with paternal age of 35 years or more was 1.56 for first trimester spontaneous abortion and 0.87 for early second trimester spontaneous abortion (test of interaction, p = 0.25). In conclusion, the risk of spontaneous abortion increased with increasing paternal age, with a suggestion that the association is stronger for first trimester losses.

Keywords: abortion, spontaneous; confounding factors (epidemiology); maternal age; paternal age; pregnancy; HR, hazard ratio

Journal Article.  5596 words.  Illustrated.

Subjects: Public Health and Epidemiology

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