Journal Article

Prospective Study of Dietary Fat and Risk of Cataract Extraction among US Women

Minyi Lu, Eunyoung Cho, Allen Taylor, Susan E. Hankinson, Walter C. Willett and Paul F. Jacques

in American Journal of Epidemiology

Published on behalf of Johns Hopkins Bloomberg School of Public Health

Volume 161, issue 10, pages 948-959
Published in print May 2005 | ISSN: 0002-9262
Published online May 2005 | e-ISSN: 1476-6256 | DOI:
Prospective Study of Dietary Fat and Risk of Cataract Extraction among US Women

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The authors examined prospectively the association between dietary fat intake and cataract extraction in adult women from the Nurses' Health Study. A total of 71,083 women were followed prospectively for up to 16 years between 1984 and 2000. Dietary fat was assessed by repeated food frequency questionnaires. Incident cases of cataract extraction were determined by a biennial questionnaire. The multivariate-adjusted relative risk for the highest compared with the lowest quintile of total fat intake was 1.10 (95% confidence interval (CI): 0.99, 1.22; ptrend = 0.01). Women in the highest quintile of long-chain omega-3 fatty acid had a 12% lower risk of cataract extraction compared with those in the lowest quintile (relative risk = 0.88, 95% CI: 0.79, 0.98; ptrend = 0.02). Total fish intake was inversely associated with cataract (for intake of ≥3/week vs. <1/month: relative risk = 0.89, 95% CI: 0.81, 0.98; ptrend = 0.01). The authors' findings suggest that higher intake of long-chain omega-3 fatty acid (eicosapentaenoic acid and docosahexaenoic acid) and consumption of fish may modestly reduce the risk of cataract.

Keywords: cataract extraction; dietary fats; fatty acids, omega-3; trans fatty acids; CI, confidence interval

Journal Article.  7215 words. 

Subjects: Public Health and Epidemiology

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