Journal Article

Effect of Adiposity and Fat Distribution on Endometrial Cancer Risk in Shanghai Women

Wang Hong Xu, Charles E. Matthews, Yong Bing Xiang, Wei Zheng, Zhi Xian Ruan, Jia Rong Cheng, Yu Tang Gao and Xiao Ou Shu

in American Journal of Epidemiology

Published on behalf of Johns Hopkins Bloomberg School of Public Health

Volume 161, issue 10, pages 939-947
Published in print May 2005 | ISSN: 0002-9262
Published online May 2005 | e-ISSN: 1476-6256 | DOI:
Effect of Adiposity and Fat Distribution on Endometrial Cancer Risk in Shanghai Women

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The authors conducted a population-based case-control study of 832 endometrial cancer cases and 846 frequency-matched controls in Shanghai, China (1997–2001), to examine the association of overall adiposity and body fat distribution with disease risk. Overall adiposity was estimated using weight and body mass index (BMI); upper body fat distribution was evaluated using waist circumference and waist:hip ratio. Overall and upper-body obesity were both associated with an elevated risk of endometrial cancer. Adjusted odds ratios and 95% confidence intervals for highest-versus-lowest quartile comparisons were 2.6 (95% confidence interval (CI): 2.0, 3.5) for weight, 2.9 (95% CI: 2.2, 3.9) for BMI, 4.7 (95% CI: 3.4, 6.4) for waist circumference, and 3.5 (95% CI: 2.6, 4.8) for waist:hip ratio. The positive associations with weight and BMI vanished after results were controlled for waist circumference, while associations with waist circumference and waist:hip ratio persisted after adjustment for BMI. The positive association with upper-body obesity was more pronounced among younger women, women who had never used oral contraceptives, and women with a history of diabetes mellitus (p for multiplicative interaction < 0.05). Upper-body obesity was related to increased risk among women with low BMI. These results suggest that obesity, particularly upper-body fat deposition, is associated with an increased risk of endometrial cancer.

Keywords: body composition; body mass index; case-control studies; endometrial neoplasms; obesity; BMI, body mass index; CI, confidence interval; IGF-1, insulin-like growth factor 1

Journal Article.  5191 words. 

Subjects: Public Health and Epidemiology

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