Journal Article

Obesity before Age 30 Years and Risk of Advanced Prostate Cancer

Whitney R. Robinson, June Stevens, Marilie D. Gammon and Esther M. John

in American Journal of Epidemiology

Published on behalf of Johns Hopkins Bloomberg School of Public Health

Volume 161, issue 12, pages 1107-1114
Published in print June 2005 | ISSN: 0002-9262
Published online June 2005 | e-ISSN: 1476-6256 | DOI: http://dx.doi.org/10.1093/aje/kwi150
Obesity before Age 30 Years and Risk of Advanced Prostate Cancer

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Adult obesity has shown little association with prostate cancer risk, but obesity at younger ages may be associated with reduced risk. In 1997–2000, the relation between obesity before age 30 years and incident advanced prostate cancer was investigated in a population-based case-control study of African-American and White men (568 cases, 544 controls) in California. Unconditional logistic regression was used to estimate odds ratios and 95% confidence intervals, adjusted for age, race, family history of prostate cancer, and saturated fat intake. Measures of obesity for age 10 years tended to be inversely associated with prostate cancer (odds ratio (OR) = 0.79, 95% confidence interval (CI): 0.46, 1.38 for selecting the “obese” pictogram and OR = 0.76, 95% CI: 0.52, 1.11 for reporting being heavier than peers). The decreased risk was more pronounced at ages 20–29 years (OR = 0.53, 95% CI: 0.28, 1.00 for the “obese” drawing, OR = 0.59, 95% CI: 0.40, 0.88 for being heavier than peers, and OR = 0.40, 95% CI: 0.20, 0.81 for body mass index ≥30 kg/m2). In addition, both “obese” and small waist size at ages 20–29 years showed inverse trends. This research implicating early-life body size in prostate cancer development helps to elucidate causal mechanisms, such as altered sex hormone profiles during critical developmental periods, potentially involved in development of the disease.

Keywords: age factors; body mass index; body size; case-control studies; child; obesity; prostatic neoplasms; risk factors; BMI, body mass index; CI, confidence interval; OR, odds ratio

Journal Article.  5714 words. 

Subjects: Public Health and Epidemiology

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