Journal Article

Systematic Review and Meta-Analysis of the Association between β<sub>2</sub>-Adrenoceptor Polymorphisms and Asthma: A HuGE Review

Ammarin Thakkinstian, Mark McEvoy, Cosetta Minelli, Peter Gibson, Bob Hancox, David Duffy, John Thompson, Ian Hall, Joel Kaufman, Ting-fan Leung, Peter Joseph Helms, Hakon Hakonarson, Eva Halpi, Ruth Navon and John Attia

in American Journal of Epidemiology

Published on behalf of Johns Hopkins Bloomberg School of Public Health

Volume 162, issue 3, pages 201-211
Published in print August 2005 | ISSN: 0002-9262
Published online August 2005 | e-ISSN: 1476-6256 | DOI:
Systematic Review and Meta-Analysis of the Association between β2-Adrenoceptor Polymorphisms and Asthma: A HuGE Review

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A number of studies have investigated two common polymorphisms in the β2-adrenoceptor gene, Arg/Gly16 and Gln/Glu27, in relation to asthma susceptibility. The authors performed a meta-analysis of each polymorphism, as well as haplotype analysis, for adult and pediatric populations separately, using published data, supplemented by additional data requested from the original authors. Individual analysis detected no effect of Arg/Gly16 in adults but did suggest a recessive protective effect of Gly16 for children, with an odds ratio of 0.71 (95% confidence interval (CI): 0.53, 0.96) compared with the other genotypes. Results for Gln/Glu27 in adults seem to indicate that heterozygotes are at decreased risk of asthma than either homozygote (odds ratio = 0.73, 95% CI: 0.62, 0.87), although the studies are heterogeneous; in children, the Glu/Glu genotype has a decreased risk of asthma (odds ratio = 0.60, 95% CI: 0.35, 0.99) compared with the other genotypes. Despite the proximity of these two polymorphic sites, the linkage disequilibrium coefficient of 0.41 was not high (p < 0.001). Haplotype analysis suggests that there may be an interaction between the two sites, with a lower risk of asthma associated with the Glu27 allele (compared with Gln27), and that this risk is modified by the allele at position 16.

Keywords: asthma; epidemiology; genetics; haplotypes; linkage disequilibrium; meta-analysis; polymorphism, genetic; receptors, adrenergic; CI, confidence interval; LR, likelihood ratio; OR, odds ratio; SNP, single-nucleotide polymorphism

Journal Article.  6880 words. 

Subjects: Public Health and Epidemiology

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