Journal Article

Evidence for Excess Colorectal Cancer Incidence among Asbestos-exposed Men in the Beta-Carotene and Retinol Efficacy Trial

Oluremi A. Aliyu, Mark R. Cullen, Matt J. Barnett, John R. Balmes, Brenda Cartmel, Carrie A. Redlich, Carl A. Brodkin, Scott Barnhart, Linda Rosenstock, Leslie Israel, Gary E. Goodman, Mark D. Thornquist and Gilbert S. Omenn

in American Journal of Epidemiology

Published on behalf of Johns Hopkins Bloomberg School of Public Health

Volume 162, issue 9, pages 868-878
Published in print November 2005 | ISSN: 0002-9262
Published online September 2005 | e-ISSN: 1476-6256 | DOI: https://dx.doi.org/10.1093/aje/kwi285
Evidence for Excess Colorectal Cancer Incidence among Asbestos-exposed Men in the Beta-Carotene and Retinol Efficacy Trial

Show Summary Details

Preview

The relation between asbestos exposure and colorectal cancer remains controversial. The authors of this 1984–2004 US study examined the association among 3,897 occupationally exposed participants in the Beta-Carotene and Retinol Efficacy Trial (CARET) for chemoprevention of lung cancer, followed prospectively for 10–18 years. When a Cox stratified proportional hazards model was used, risks of colorectal cancer were elevated among male heavy smokers exposed to asbestos. Their relative risk was 1.36 (95% confidence interval: 0.96, 1.93) when compared with that for CARET heavy smokers not exposed to asbestos, after adjusting for age, smoking history, and intervention arm. The presence of asbestos-induced pleural plaques at baseline was associated with a relative risk of 1.54 (95% confidence interval: 0.99, 2.40); colorectal cancer risk also increased with worsening pulmonary asbestosis (p = 0.03 for trend). A dose-response trend based on years of asbestos exposure was less evident. Nonetheless, these data suggest that colorectal cancer risk is elevated among men occupationally exposed to asbestos, especially those with evidence of nonmalignant asbestos-associated radiographic changes.

Keywords: asbestos; asbestosis; colorectal neoplasms; environmental exposure; prospective studies; randomized controlled trials; smoking; CARET, Beta-Carotene and Retinol Efficacy Trial; CI, confidence interval

Journal Article.  6260 words.  Illustrated.

Subjects: Public Health and Epidemiology

Full text: subscription required

How to subscribe Recommend to my Librarian

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content.