Journal Article

Ghrelin, Adiponectin, and Leptin Do Not Predict Long-term Changes in Weight and Body Mass Index in Older Adults: Longitudinal Analysis of the Rancho Bernardo Cohort

Claudia Langenberg, Jaclyn Bergstrom, Gail A. Laughlin and Elizabeth Barrett-Connor

in American Journal of Epidemiology

Published on behalf of Johns Hopkins Bloomberg School of Public Health

Volume 162, issue 12, pages 1189-1197
Published in print December 2005 | ISSN: 0002-9262
Published online October 2005 | e-ISSN: 1476-6256 | DOI: http://dx.doi.org/10.1093/aje/kwi338
Ghrelin, Adiponectin, and Leptin Do Not Predict Long-term Changes in Weight and Body Mass Index in Older Adults: Longitudinal Analysis of the Rancho Bernardo Cohort

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Ghrelin, leptin, and adiponectin are associated with body size in cross-sectional studies; it is unknown whether these hormones predict long-term changes in body size. Multilevel models were used to study associations between fasting serum hormones, measured in 698 men and 619 women (60–91 years) in samples collected at baseline (1984–1987), and changes in weight and body mass index, assessed repeatedly over a follow-up period of up to 18 years (median, 4.7 years). Baseline weight was −1.5 kg lower for a one-standard-deviation increment in ghrelin and −3.3 kg lower for a one-standard-deviation increment in adiponectin, similar in men and women. For leptin, baseline weight was 12.1 kg higher for a one-standard-deviation increment in men, compared with 5.7 kg in women (sex-interaction p ≤ 0.0001). Ghrelin and adiponectin did not affect weight change; their associations with weight were constant over time, indicated by nonsignificant hormone-by-time interactions. The positive association between leptin and weight became slightly weaker over time. Results were similar when investigating repeated measures of body mass index. From this analysis of Rancho Bernardo Study data, the authors conclude that ghrelin, adiponectin, and leptin do not predict weight gain beyond reflecting the influence of attained body size on future changes in weight or body mass index.

Keywords: adipocytes; body weight changes; leptin; longitudinal studies; obesity; peptide hormones; CI, confidence interval

Journal Article.  6442 words.  Illustrated.

Subjects: Public Health and Epidemiology

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