Journal Article

Physical Activity, Obesity, Energy Intake, and the Risk of Non-Hodgkin's Lymphoma: A Population-based Case-Control Study

Sai Yi Pan, Yang Mao and Anne-Marie Ugnat

in American Journal of Epidemiology

Published on behalf of Johns Hopkins Bloomberg School of Public Health

Volume 162, issue 12, pages 1162-1173
Published in print December 2005 | ISSN: 0002-9262
Published online November 2005 | e-ISSN: 1476-6256 | DOI: http://dx.doi.org/10.1093/aje/kwi342
Physical Activity, Obesity, Energy Intake, and the Risk of Non-Hodgkin's Lymphoma: A Population-based Case-Control Study

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The authors conducted a population-based case-control study of 1,030 cases with histologically confirmed, incident non-Hodgkin's lymphoma (NHL) and 3,106 controls to assess the impact of recreational physical activity, obesity, and energy intake on NHL risk in Canada from 1994 to 1997. Compared with those for subjects in the lowest quartiles of total recreational physical activity, multivariable-adjusted odds ratios for subjects in the highest quartile were 0.79 (95% confidence interval (CI): 0.59, 1.05) for men and 0.59 (95% CI: 0.42, 0.81) for women. Obesity (body mass index ≥30 kg/m2) was associated with odds ratios of 1.59 (95% CI: 1.18, 2.12) for men and 1.36 (95% CI: 1.00, 1.84) for women. For men and women with a lifetime maximum body mass index of ≥30 kg/m2, respective odds ratios were 1.55 (95% CI: 1.16, 2.06) and 1.10 (95% CI: 0.83, 1.46). For men and women in the highest quartiles of calorie intake, respective odds ratios were 1.95 (95% CI: 1.45, 2.62) and 1.13 (95% CI: 0.84, 1.52). Some differences were found between histologic subtypes of NHL for these associations. This study suggests that recreational physical activity decreases NHL risk, while obesity and excess calorie intake increase it. More studies are needed to confirm these results, especially the differences between histologic subtypes.

Keywords: case-control studies; energy intake; exercise; lymphoma, non-Hodgkin; obesity; recreation; BMI, body mass index; CI, confidence interval; MET, metabolic equivalent task; NHL, non-Hodgkin's lymphoma

Journal Article.  6666 words. 

Subjects: Public Health and Epidemiology

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