Journal Article

Time Course of Nicotine and Cotinine Incorporation into Samples of Nonsmokers' Beard Hair Following a Single Dose of Nicotine Polacrilex*

John T. Bernert, Joseph R. Alexander, Connie S. Sosnoff and James E. McGuffey

in Journal of Analytical Toxicology

Volume 35, issue 1, pages 1-7
Published in print January 2011 | ISSN: 0146-4760
Published online January 2011 | e-ISSN: 1945-2403 | DOI: http://dx.doi.org/10.1093/anatox/35.1.1
Time Course of Nicotine and Cotinine Incorporation into Samples of Nonsmokers' Beard Hair Following a Single Dose of Nicotine Polacrilex*

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Hair nicotine and cotinine have been proposed as longer-term markers of exposure to secondhand smoke. In this study, we evaluated the rate and extent of nicotine and cotinine deposition into beard hair among six male nonsmokers following a single exposure to 4 mg of nicotine in Nicorette® (nicotine polacrilex) gum. We collected beard hair samples daily for 12 days following exposure and urine samples for 6 days after exposure. Using liquid chromatographic-tandem mass spectrometric analysis, we found that both nicotine and cotinine could be detected in beard samples within 24 h of the exposure and reached a maximum of about 71 pg nicotine and 47 pg cotinine/mg hair, respectively, within 1–2 days, followed by a gradual decline. Compared to beard hair concentrations, nicotine, cotinine, and hydroxycotinine were excreted in urine at much higher levels and also peaked on the day after exposure (mean ± SD urine cotinine = 300 ± 183 ng/mL). Our results confirmed that both nicotine and cotinine can be measured in beard hair samples following a single dose of nicotine. However, both the time-course and extent of deposition of these analytes in beard hair in this study differed from the results reported previously from a similar evaluation.

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Subjects: Medical Toxicology ; Toxicology (Non-medical)

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