Journal Article

Dimethylamylamine: A Drug Causing Positive Immunoassay Results for Amphetamines*

Shawn P. Vorce, Justin M. Holler, Brian M. Cawrse and Joseph Magluilo

in Journal of Analytical Toxicology

Volume 35, issue 3, pages 183-187
Published in print April 2011 | ISSN: 0146-4760
Published online April 2011 | e-ISSN: 1945-2403 | DOI: http://dx.doi.org/10.1093/anatox/35.3.183
Dimethylamylamine: A Drug Causing Positive Immunoassay Results for Amphetamines*

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The Department of Defense (DoD) operates six forensic urine drug-testing laboratories that screen close to 5 million urine samples for amphetamines yearly. Recently, the DoD laboratories have observed a significant decrease in the confirmation rates for amphetamines because of specimens screening positive by two separate immunoassays and confirming negative by gas chromatography-mass spectrometry (GC-MS). Previous studies conducted by the Division of Forensic Toxicology, Armed Force Institute of Pathology (AFIP) utilizing a GC-MS basic drug screen and a designer drug screen revealed no common compound or compound classes as to the cause of the immunoassay-positive results. Additional information obtained from an immunoassay vendor suggested the anorectic compound dimethylamylamine (DMAA) may be the cause of the false-positive screens. An additional 134 false-positive samples were received and analyzed using liquid chromatography-tandem mass spectrometry (LC-MS-MS) for DMAA. LC-MS-MS analysis revealed the presence of DMAA in 92.3% of the false-positive samples at a concentration of approximately 6.0 mg/L DMAA, causing a positive screen on both immunoassay kits.

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Subjects: Medical Toxicology ; Toxicology (Non-medical)

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