Journal Article

Fatal Intoxication Due to Brucine

Jörg Teske, Jens-Peter Weller, Urs-Vito Albrecht and Armin Fieguth

in Journal of Analytical Toxicology

Volume 35, issue 4, pages 248-253
Published in print May 2011 | ISSN: 0146-4760
Published online May 2011 | e-ISSN: 1945-2403 | DOI: http://dx.doi.org/10.1093/anatox/35.4.248
Fatal Intoxication Due to Brucine

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A sensitive method for identifying and quantifying brucine by means of liquid chromatography-tandem mass spectrometry is presented in this article. Based on a solid-phase extraction for human serum, the validation indicated limits of detection and quantification of 0.12 and 0.23 ng/mL, respectively. In one case of lethal suicidal brucine monointoxication, brucine concentrations of 1.51 µg/mL, 1.69 µg/mL, 9.94 µg/mL, 16.4 µg/g, 0.99 µg/g, 0.75 µg/g, and 1.95 mg/g were determined in femoral blood, urine, bile collected from the gallbladder, liver tissue, cerebellum, cerebrum, and stomach contents, respectively.

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Subjects: Medical Toxicology ; Toxicology (Non-medical)

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