Journal Article

The interface between metabolic and stress signalling

Sandra J. Hey, Edward Byrne and Nigel G. Halford

in Annals of Botany

Published on behalf of The Annals of Botany Company

Volume 105, issue 2, pages 197-203
Published in print February 2010 | ISSN: 0305-7364
Published online December 2009 | e-ISSN: 1095-8290 | DOI: http://dx.doi.org/10.1093/aob/mcp285
The interface between metabolic and stress signalling

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  • Ecology and Conservation
  • Evolutionary Biology
  • Plant Sciences and Forestry

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Background

It is becoming increasingly clear that stress and metabolic signalling networks interact and that this interaction is important in plant responses to herbivory, pathogen attack, drought, cold, heat and osmotic stresses including salinity. At the interface between these two major signalling systems are the hormone abscisic acid (ABA) and signalling factors including protein kinases and transcription factors.

Scope

This briefing reviews links between ABA, stress and sugar signalling, focusing on the roles of sucrose non-fermenting-1-related protein kinases (SnRKs), SnRK1-activating protein kinases (SnAKs), calcium-dependent protein kinases (CDPKs) and ABA response element binding proteins (AREBPs, which are transcription factors). Links between stress and nitrogen / amino acid signalling are also described, including the roles of a protein kinase called general control non-derepressible (GCN)-2 in regulating protein synthesis through phosphorylation of the α-subunit of translation initiation factor-2 (eIF2α) in response not only to decreases in amino acid levels but also to a range of stresses. Evidence of a link between sugar and amino acid signalling is explored, with nitrate reductase being a target for regulation by both SnRK1 and GCN2 through different mechanisms; possible links between SnRK1 and GCN2 via a pathway including the protein kinase target of rapamycin (TOR)-1 are described. The significance of these interactions to the concept of signalling networks as opposed to simple cascades and pathways, and the importance of the subject in the context of the predicted increase in severity and range of stresses that plants will have to withstand as a result of global climate change are discussed.

Keywords: ABA (abscisic acid); AREBP (ABA response element binding protein); CDPK (calcium-dependent protein kinase); climate change; GCN2 (general control non-derepressible 2); metabolic signalling; protein kinase; signalling networks; SnAK (SnRK1-activating protein kinase); SnRK (sucrose non-fermenting-1-related protein kinase); stress signalling; transcription factor

Journal Article.  4745 words.  Illustrated.

Subjects: Ecology and Conservation ; Evolutionary Biology ; Plant Sciences and Forestry

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