Journal Article

Biological function through network topology: a survey of the human diseasome

Vuk Janjić and Nataša Pržulj

in Briefings in Functional Genomics

Volume 11, issue 6, pages 522-532
Published in print November 2012 | ISSN: 2041-2649
Published online September 2012 | e-ISSN: 2041-2647 | DOI: http://dx.doi.org/10.1093/bfgp/els037
Biological function through network topology: a survey of the human diseasome

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Molecular network data are increasingly becoming available, necessitating the development of well performing computational tools for their analyses. Such tools enabled conceptually different approaches for exploring human diseases to be undertaken, in particular, those that study the relationship between a multitude of biomolecules within a cell. Hence, a new field of network biology has emerged as part of systems biology, aiming to untangle the complexity of cellular network organization. We survey current network analysis methods that aim to give insight into human disease.

Keywords: biological networks; network topology; human diseasome

Journal Article.  5911 words.  Illustrated.

Subjects: Genetics and Genomics

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