Journal Article

Toward the dynamic interactome: it's about time

Teresa M. Przytycka, Mona Singh and Donna K. Slonim

in Briefings in Bioinformatics

Volume 11, issue 1, pages 15-29
Published in print January 2010 | ISSN: 1467-5463
Published online January 2010 | e-ISSN: 1477-4054 | DOI: http://dx.doi.org/10.1093/bib/bbp057
Toward the dynamic interactome: it's about time

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Dynamic molecular interactions play a central role in regulating the functioning of cells and organisms. The availability of experimentally determined large-scale cellular networks, along with other high-throughput experimental data sets that provide snapshots of biological systems at different times and conditions, is increasingly helpful in elucidating interaction dynamics. Here we review the beginnings of a new subfield within computational biology, one focused on the global inference and analysis of the dynamic interactome. This burgeoning research area, which entails a shift from static to dynamic network analysis, promises to be a major step forward in our ability to model and reason about cellular function and behavior.

Keywords: network analysis; network dynamics; interaction networks; systems biology

Journal Article.  8506 words. 

Subjects: Bioinformatics and Computational Biology

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