Journal Article

Maximum likelihood estimates of allele frequencies and error rates from samples of related individuals by gene counting

Alun Thomas and Nicola J. Camp

in Bioinformatics

Volume 22, issue 6, pages 771-772
Published in print March 2006 | ISSN: 1367-4803
Published online January 2006 | e-ISSN: 1460-2059 | DOI: http://dx.doi.org/10.1093/bioinformatics/btk049
Maximum likelihood estimates of allele frequencies and error rates from samples of related individuals by gene counting

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Summary: Graphical modeling is used to extend the gene counting method to compute maximum likelihood estimates of allele frequencies for samples of individuals related in extended pedigrees. Genotypes may be missing or partially observed, and error rates can be simultaneously estimated.

Availability: The Java classes and Javadocs pages for [math]can be obtained from , which also has more information on its use and file formats.

Contact:alun@genepi.med.utah.edu

Journal Article.  1571 words. 

Subjects: Bioinformatics and Computational Biology

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