Journal Article

An integrated approach for automating validation of extracted ion chromatographic peaks

William D. Nelson, Kert Viele and Bert C. Lynn

in Bioinformatics

Volume 24, issue 18, pages 2103-2104
Published in print September 2008 | ISSN: 1367-4803
Published online July 2008 | e-ISSN: 1460-2059 | DOI: http://dx.doi.org/10.1093/bioinformatics/btn385
An integrated approach for automating validation of extracted ion chromatographic peaks

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Summary: Accurate determination of extracted ion chromatographic peak areas in isotope-labeled quantitative proteomics is difficult to automate. Manual validation of identified peaks is typically required. We have integrated a peak confidence scoring algorithm into existing tools which are compatible with analysis pipelines based on the standards from the Institute for Systems Biology. This algorithm automatically excludes incorrectly identified peaks, improving the accuracy of the final protein expression ratio calculation.

Contact: wnels2@uky.edu

Source and Supplementary Information: http://www.chem.uky.edu/research/lynn/Nelson.pdf

Journal Article.  1407 words.  Illustrated.

Subjects: Bioinformatics and Computational Biology

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