Journal Article

DrugViz: a Cytoscape plugin for visualizing and analyzing small molecule drugs in biological networks

Bing Xiong, Ke Liu, Jie Wu, David L. Burk, Hualiang Jiang and Jingkang Shen

in Bioinformatics

Volume 24, issue 18, pages 2117-2118
Published in print September 2008 | ISSN: 1367-4803
Published online July 2008 | e-ISSN: 1460-2059 | DOI: http://dx.doi.org/10.1093/bioinformatics/btn389
DrugViz: a Cytoscape plugin for visualizing and analyzing small molecule drugs in biological networks

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Summary: DrugViz is a Cytoscape plugin that is designed to visualize and analyze small molecules within the framework of the interactome. DrugViz can import drug–target network information in an extended SIF file format to Cytoscape and display the two-dimensional (2D) structures of small molecule nodes in a unified visualization environment. It also can identify small molecule nodes by means of three different 2D structure searching methods, namely isomorphism, substructure and fingerprint-based similarity searches. After selections, users can furthermore conduct a two-side clustering analysis on drugs and targets, which allows for a detailed analysis of the active compounds in the network, and elucidate relationships between these drugs and targets. DrugViz represents a new tool for the analysis of data from chemogenomics, metabolomics and systems biology.

Availability: DrugViz and data set used in Application are freely available for download at http://202.127.30.184:8080/software.html

Contact: jkshen@mail.shcnc.ac.cn

Journal Article.  1238 words.  Illustrated.

Subjects: Bioinformatics and Computational Biology

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