Journal Article

Peptide Finder: mapping measured molecular masses to peptides and proteins

Anastasia Alexandridou, George Th. Tsangaris, Konstantinos Vougas, Konstantina Nikita and George Spyrou

in Bioinformatics

Volume 24, issue 19, pages 2267-2269
Published in print October 2008 | ISSN: 1367-4803
Published online August 2008 | e-ISSN: 1460-2059 | DOI: http://dx.doi.org/10.1093/bioinformatics/btn413
Peptide Finder: mapping measured molecular masses to peptides and proteins

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Summary: The identification of unknown amino acid sequences of peptides as well as protein identification is of great significance in proteomics. Here, we present a publicly available web application that facilitates a high resolution mapping of measured molecular masses to peptides and proteins, irrespectively of the enzyme/digestion method used. Furthermore, multi-filtering may be applied in terms of measured mass tolerance, molecular mass and isoelectric point range as well as pattern matching to refine the results. This approach serves complementary to the existing solutions for protein identification and gives insights in novel peptides discovery and protein identification at the cases where the identification scores from the other approaches may be below significance threshold. Peptide Finder has been proven useful in proteomics procedures with experimental data from MALDI-TOF.

Availability: Peptide Finder web-application is available at http://bioserver-1.bioacademy.gr/Bioserver/PeptideFinder/.

Contact: gspyrou@bioacademy.gr

Journal Article.  1785 words.  Illustrated.

Subjects: Bioinformatics and Computational Biology

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