Journal Article

ZOOM! Zillions of oligos mapped

Hao Lin, Zefeng Zhang, Michael Q. Zhang, Bin Ma and Ming Li

in Bioinformatics

Volume 24, issue 21, pages 2431-2437
Published in print November 2008 | ISSN: 1367-4803
Published online August 2008 | e-ISSN: 1460-2059 | DOI: http://dx.doi.org/10.1093/bioinformatics/btn416
ZOOM! Zillions of oligos mapped

More Like This

Show all results sharing this subject:

  • Bioinformatics and Computational Biology

GO

Show Summary Details

Preview

Motivation: The next generation sequencing technologies are generating billions of short reads daily. Resequencing and personalized medicine need much faster software to map these deep sequencing reads to a reference genome, to identify SNPs or rare transcripts.

Results: We present a framework for how full sensitivity mapping can be done in the most efficient way, via spaced seeds. Using the framework, we have developed software called ZOOM, which is able to map the Illumina/Solexa reads of 15× coverage of a human genome to the reference human genome in one CPU-day, allowing two mismatches, at full sensitivity.

Availability: ZOOM is freely available to non-commercial users at http://www.bioinfor.com/zoom

Contact: bma@csd.uwo.ca, mli@uwaterloo.ca

Journal Article.  5687 words.  Illustrated.

Subjects: Bioinformatics and Computational Biology

Full text: subscription required

How to subscribe Recommend to my Librarian

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content.