Journal Article

A novel CHHC Zn-finger domain found in spliceosomal proteins and tRNA modifying enzymes

Antonina Andreeva and Henning Tidow

in Bioinformatics

Volume 24, issue 20, pages 2277-2280
Published in print October 2008 | ISSN: 1367-4803
Published online August 2008 | e-ISSN: 1460-2059 | DOI:

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Summary: We report a previously uncharacterized CHHC Zn-finger domain identified in spliceosomal U11-48K proteins, tRNA methyl-transferases TRM13 and gametocyte specific factors. We show that this domain behaves as an independent folding unit and that it stoichiometrically binds zinc in a one-to-one ratio. Based on the conserved sequence features we predict that this domain may function as a RNA recognition and binding module.


Supplementary information: Supplementary data are available on Bioinformatics online.

Journal Article.  2949 words.  Illustrated.

Subjects: Bioinformatics and Computational Biology

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