Journal Article

A novel CHHC Zn-finger domain found in spliceosomal proteins and tRNA modifying enzymes

Antonina Andreeva and Henning Tidow

in Bioinformatics

Volume 24, issue 20, pages 2277-2280
Published in print October 2008 | ISSN: 1367-4803
Published online August 2008 | e-ISSN: 1460-2059 | DOI: http://dx.doi.org/10.1093/bioinformatics/btn431

More Like This

Show all results sharing this subject:

  • Bioinformatics and Computational Biology

GO

Show Summary Details

Preview

Summary: We report a previously uncharacterized CHHC Zn-finger domain identified in spliceosomal U11-48K proteins, tRNA methyl-transferases TRM13 and gametocyte specific factors. We show that this domain behaves as an independent folding unit and that it stoichiometrically binds zinc in a one-to-one ratio. Based on the conserved sequence features we predict that this domain may function as a RNA recognition and binding module.

Contact: tony@mrc-lmb.cam.ac.uk

Supplementary information: Supplementary data are available on Bioinformatics online.

Journal Article.  2949 words.  Illustrated.

Subjects: Bioinformatics and Computational Biology

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content.