Journal Article

Integrating expression data with domain interaction networks

Dorothea Emig, Melissa S. Cline, Thomas Lengauer and Mario Albrecht

in Bioinformatics

Volume 24, issue 21, pages 2546-2548
Published in print November 2008 | ISSN: 1367-4803
Published online September 2008 | e-ISSN: 1460-2059 | DOI: http://dx.doi.org/10.1093/bioinformatics/btn437

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Summary: Recent studies have revealed that alternative splicing plays an important role in the observed protein and interaction diversity. Special microarrays allow for measuring gene expression at the exon level and thus for studying alternative transcripts and their corresponding protein domain architecture. We have developed the Cytoscape plugin DomainGraph that enables the visualization and detailed study of domain–domain interactions forming protein interaction networks. In addition, the integration of exon expression data supports the analysis of alternative splicing events and the characterization of their effects on the protein and domain interaction network. Different expression patterns between human tissues or cells can be identified by comparing the generated domain graphs.

Availability: The plugin DomainGraph and the online documentation are available at http://domaingraph.bioinf.mpi-inf.mpg.de.

Contact: mario.albrecht@mpi-inf.mpg.de

Journal Article.  1555 words.  Illustrated.

Subjects: Bioinformatics and Computational Biology

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