Journal Article

TESE: generating specific protein structure test set ensembles

Francesco Sirocco and Silvio C. E. Tosatto

in Bioinformatics

Volume 24, issue 22, pages 2632-2633
Published in print November 2008 | ISSN: 1367-4803
Published online September 2008 | e-ISSN: 1460-2059 | DOI:
TESE: generating specific protein structure test set ensembles

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Summary: TESE is a web server for the generation of test sets of protein sequences and structures fulfilling a number of different criteria. At least three different use cases can be envisaged: (i) benchmarking of novel methods; (ii) test sets tailored for special needs and (iii) extending available datasets. The CATH structure classification is used to control structural/sequence redundancy and a variety of structural quality parameters can be used to interactively select protein subsets with specific characteristics, e.g. all X-ray structures of α-helical repeat proteins with more than 120 residues and resolution <2.0 Å. The output includes FASTA-formatted sequences, PDB files and a clickable HTML index file containing images of the selected proteins. Multiple subsets for cross-validation are also supported.

Availability: The TESE server is available for non-commercial use at URL:


Journal Article.  1001 words.  Illustrated.

Subjects: Bioinformatics and Computational Biology

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