Journal Article

Functional modules integrating essential cellular functions are predictive of the response of leukaemia cells to DNA damage

Katrin Sameith, Philipp Antczak, Elliot Marston, Nil Turan, Dieter Maier, Tanja Stankovic and Francesco Falciani

in Bioinformatics

Volume 24, issue 22, pages 2602-2607
Published in print November 2008 | ISSN: 1367-4803
Published online September 2008 | e-ISSN: 1460-2059 | DOI: http://dx.doi.org/10.1093/bioinformatics/btn489
Functional modules integrating essential cellular functions are predictive of the response of leukaemia cells to DNA damage

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Motivation: Childhood B-precursor lymphoblastic leukaemia (ALL) is the most common paediatric malignancy. Despite the fact that 80% of ALL patients respond to anti-cancer drugs, the patho-physiology of this disease is still not fully understood. mRNA expression-profiling studies that have been performed have not yet provided novel insights into the mechanisms behind cellular response to DNA damage. More powerful data analysis techniques may be required for identifying novel functional pathways involved in the cellular responses to DNA damage.

Results: In order to explore the possibility that unforeseen biological processes may be involved in the response to DNA damage, we have developed and applied a novel procedure for the identification of functional modules in ALL cells. We have discovered that the overall activity of functional modules integrating protein degradation and mRNA processing is predictive of response to DNA damage.

Availability: Supplementary material including R code, additional results, experimental datasets, as well as a detailed description of the methodology are available at http://www.bip.bham.ac.uk/vivo/fumo.html.

Contact: f.falciani@bham.ac.uk

Supplementary information: Supplementary data are available at Bioinformatics online.

Journal Article.  4661 words.  Illustrated.

Subjects: Bioinformatics and Computational Biology

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