Journal Article

FunNet: an integrative tool for exploring transcriptional interactions

Edi Prifti, Jean-Daniel Zucker, Karine Clement and Corneliu Henegar

in Bioinformatics

Volume 24, issue 22, pages 2636-2638
Published in print November 2008 | ISSN: 1367-4803
Published online September 2008 | e-ISSN: 1460-2059 | DOI: http://dx.doi.org/10.1093/bioinformatics/btn492
FunNet: an integrative tool for exploring transcriptional interactions

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Summary: We describe here an exploratory tool, called FunNet, which implements an original systems biology approach, aiming to improve the biological relevance of the modular interaction patterns identified in transcriptional co-expression networks. A suitable analytical model, involving two abstraction layers, has been devised to relate expression profiles to the knowledge on transcripts’ biological roles, extracted from genomic databases, into a comprehensive exploratory framework. This approach has been implemented into a user-friendly web tool to promote its open use by the community.

Availability: http://www.funnet.info

Contact: edi.prifti@crc.jussieu.fr

Journal Article.  1361 words.  Illustrated.

Subjects: Bioinformatics and Computational Biology

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