Journal Article

MSX-3D: a tool to validate 3D protein models using mass spectrometry

Michaël Heymann, David Paramelle, Gilles Subra, Eric Forest, Jean Martinez, Christophe Geourjon and Gilbert Deléage

in Bioinformatics

Volume 24, issue 23, pages 2782-2783
Published in print December 2008 | ISSN: 1367-4803
Published online September 2008 | e-ISSN: 1460-2059 | DOI: http://dx.doi.org/10.1093/bioinformatics/btn510
MSX-3D: a tool to validate 3D protein models using mass spectrometry

More Like This

Show all results sharing this subject:

  • Bioinformatics and Computational Biology

GO

Show Summary Details

Preview

Motivation: The technique of chemical cross-linking followed by mass spectrometry has proven to bring valuable information about the protein structure and interactions between proteic subunits. It is an effective and efficient way to experimentally investigate some aspects of a protein structure when NMR and X-ray crystallography data are lacking.

Results: We introduce MSX-3D, a tool specifically geared to validate protein models using mass spectrometry. In addition to classical peptides identifications, it allows an interactive 3D visualization of the distance constraints derived from a cross-linking experiment.

Availability: Freely available at http://proteomics-pbil.ibcp.fr

Contact: g.deleage@ibcp.fr

Journal Article.  948 words.  Illustrated.

Subjects: Bioinformatics and Computational Biology

Full text: subscription required

How to subscribe Recommend to my Librarian

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content.