Journal Article

FABSIM: a software for generating <i>F</i><sub><i>ST</i></sub> distributions with various ascertainment biases

Anna Ramírez-Soriano and Francesc Calafell

in Bioinformatics

Volume 24, issue 23, pages 2790-2791
Published in print December 2008 | ISSN: 1367-4803
Published online October 2008 | e-ISSN: 1460-2059 | DOI: http://dx.doi.org/10.1093/bioinformatics/btn531
FABSIM: a software for generating FST distributions with various ascertainment biases

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Summary: We have developed a software that applies ascertainment bias on simulated DNA sequences and calculates FST on them, so they can be used to generate neutral distributions that are appropriate to test whether the genetic differentiation of a particular gene between populations is compatible with neutral evolution, or, on the contrary, suggests local adaptation by natural selection.

Availability: FABSIM is available from http://www.snpator.com/public/downloads/aRamirez/FABSIM/.

Contact: francesc.calafell@upf.edu.

Supplementary information: Supplementary data are available at Bioinformatics online. The data from which figures are built can be dowloaded from http://www.snpator.com/public/downloads/aRamirez/.

Journal Article.  1453 words.  Illustrated.

Subjects: Bioinformatics and Computational Biology

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