Journal Article

SPOCTOPUS: a combined predictor of signal peptides and membrane protein topology

Håkan Viklund, Andreas Bernsel, Marcin Skwark and Arne Elofsson

in Bioinformatics

Volume 24, issue 24, pages 2928-2929
Published in print December 2008 | ISSN: 1367-4803
Published online October 2008 | e-ISSN: 1460-2059 | DOI: https://dx.doi.org/10.1093/bioinformatics/btn550
SPOCTOPUS: a combined predictor of signal peptides and membrane protein topology

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Summary: SPOCTOPUS is a method for combined prediction of signal peptides and membrane protein topology, suitable for genome-scale studies. Its objective is to minimize false predictions of transmembrane regions as signal peptides and vice versa. We provide a description of the SPOCTOPUS algorithm together with a performance evaluation where SPOCTOPUS compares favorably with state-of-the-art methods for signal peptide and topology predictions.

Availability: SPOCTOPUS is available as a web server and both the source code and benchmark data are available for download at http://octopus.cbr.su.se/

Contact: arne@bioinfo.se

Supplementary information: Supplementary data are available at Bioinformatics online.

Journal Article.  1526 words. 

Subjects: Bioinformatics and Computational Biology

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