Journal Article

SNAP: a web-based tool for identification and annotation of proxy SNPs using HapMap

Andrew D. Johnson, Robert E. Handsaker, Sara L. Pulit, Marcia M. Nizzari, Christopher J. O'Donnell and Paul I. W. de Bakker

in Bioinformatics

Volume 24, issue 24, pages 2938-2939
Published in print December 2008 | ISSN: 1367-4803
Published online October 2008 | e-ISSN: 1460-2059 | DOI: http://dx.doi.org/10.1093/bioinformatics/btn564
SNAP: a web-based tool for identification and annotation of proxy SNPs using HapMap

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Summary: The interpretation of genome-wide association results is confounded by linkage disequilibrium between nearby alleles. We have developed a flexible bioinformatics query tool for single-nucleotide polymorphisms (SNPs) to identify and to annotate nearby SNPs in linkage disequilibrium (proxies) based on HapMap. By offering functionality to generate graphical plots for these data, the SNAP server will facilitate interpretation and comparison of genome-wide association study results, and the design of fine-mapping experiments (by delineating genomic regions harboring associated variants and their proxies).

Availability: SNAP server is available at http://www.broad.mit.edu/mpg/snap/.

Contact: debakker@broad.mit.edu

Journal Article.  1123 words.  Illustrated.

Subjects: Bioinformatics and Computational Biology

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