Journal Article

Ultrasome: efficient aberration caller for copy number studies of ultra-high resolution

Björn Nilsson, Mikael Johansson, Fatima Al-Shahrour, Anne E. Carpenter and Benjamin L. Ebert

in Bioinformatics

Volume 25, issue 8, pages 1078-1079
Published in print April 2009 | ISSN: 1367-4803
Published online February 2009 | e-ISSN: 1460-2059 | DOI: http://dx.doi.org/10.1093/bioinformatics/btp091
Ultrasome: efficient aberration caller for copy number studies of ultra-high resolution

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Motivation: Multimillion-probe microarrays allow detection of gains and losses of chromosomal material at unprecedented resolution. However, the data generated by these arrays are several-fold larger than data from earlier platforms, creating a need for efficient analysis tools that scale robustly with data size.

Results: We developed a new aberration caller, Ultrasome, that delineates genomic changes-of-interest with dramatically improved efficiency. Ultrasome shows near-linear computational complexity and processes latest generation copy number arrays about 10 000 times faster than standard methods with preserved analytic accuracy.

Availability: www.broad.mit.edu/ultrasome.

Contact: bnilsson@broad.mit.edu

Supplementary information: Supplementary data are available at Bioinformatics online.

Journal Article.  992 words.  Illustrated.

Subjects: Bioinformatics and Computational Biology

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