Journal Article

iMembrane: homology-based membrane-insertion of proteins

Sebastian Kelm, Jiye Shi and Charlotte M. Deane

in Bioinformatics

Volume 25, issue 8, pages 1086-1088
Published in print April 2009 | ISSN: 1367-4803
Published online February 2009 | e-ISSN: 1460-2059 | DOI:

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Summary: iMembrane is a homology-based method, which predicts a membrane protein's position within a lipid bilayer. It projects the results of coarse-grained molecular dynamics simulations onto any membrane protein structure or sequence provided by the user. iMembrane is simple to use and is currently the only computational method allowing the rapid prediction of a membrane protein's lipid bilayer insertion. Bilayer insertion data are essential in the accurate structural modelling of membrane proteins or the design of drugs that target them.

Availability: iMembrane is available under a non-commercial open-source licence, upon request.


Supplementary information: Supplementary data are available at Bioinformatics online and at

Journal Article.  1513 words.  Illustrated.

Subjects: Bioinformatics and Computational Biology

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