Journal Article

PLATINUM: a web tool for analysis of hydrophobic/hydrophilic organization of biomolecular complexes

Timothy V. Pyrkov, Anton O. Chugunov, Nikolay A. Krylov, Dmitry E. Nolde and Roman G. Efremov

in Bioinformatics

Volume 25, issue 9, pages 1201-1202
Published in print May 2009 | ISSN: 1367-4803
Published online February 2009 | e-ISSN: 1460-2059 | DOI: http://dx.doi.org/10.1093/bioinformatics/btp111
PLATINUM: a web tool for analysis of hydrophobic/hydrophilic organization of biomolecular complexes

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Summary: The PLATINUM (Protein–Ligand ATtractions Investigation NUMerically) web service is designed for analysis and visualization of hydrophobic/hydrophilic properties of biomolecules supplied as 3D-structures. Furthermore, PLATINUM provides a number of tools for quantitative characterization of the hydrophobic/hydrophilic match in biomolecular complexes e.g. in docking poses. These complement standard scoring functions. The calculations are based on the concept of empirical Molecular Hydrophobicity Potential (MHP).

Availability: The PLATINUM web tool as well as detailed documentation and tutorial are available free of charge for academic users at http://model.nmr.ru/platinum/. PLATINUM requires Java 5 or higher and Adobe Flash Player 9.

Contact: pyrkov@nmr.ru

Supplementary information: Supplementary data are available at Bioinformatics online.

Journal Article.  1268 words.  Illustrated.

Subjects: Bioinformatics and Computational Biology

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