Journal Article

A web server for inferring the human <i>N</i>-acetyltransferase-2 (NAT2) enzymatic phenotype from <i>NAT2</i> genotype

Igor B. Kuznetsov, Michael McDuffie and Roxana Moslehi

in Bioinformatics

Volume 25, issue 9, pages 1185-1186
Published in print May 2009 | ISSN: 1367-4803
Published online March 2009 | e-ISSN: 1460-2059 | DOI: http://dx.doi.org/10.1093/bioinformatics/btp121

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Summary:N-acetyltransferase-2 (NAT2) is an important enzyme that catalyzes the acetylation of aromatic and heterocyclic amine carcinogens. Individuals in human populations are divided into three NAT2 acetylator phenotypes: slow, rapid and intermediate. NAT2PRED is a web server that implements a supervised pattern recognition method to infer NAT2 phenotype from SNPs found in NAT2 gene positions 282, 341, 481, 590, 803 and 857. The web server can be used for a fast determination of NAT2 phenotypes in genetic screens.

Availability:Freely available at http://nat2pred.rit.albany.edu

Contact:ikuznetsov@albany.edu; rmoslehi@albany.edu

Supplementary information:Supplementary data are available at Bioinformatics online.

Journal Article.  1461 words.  Illustrated.

Subjects: Bioinformatics and Computational Biology

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