Journal Article

SpliceAid: a database of experimental RNA target motifs bound by splicing proteins in humans

Francesco Piva, Matteo Giulietti, Linda Nocchi and Giovanni Principato

in Bioinformatics

Volume 25, issue 9, pages 1211-1213
Published in print May 2009 | ISSN: 1367-4803
Published online March 2009 | e-ISSN: 1460-2059 | DOI: http://dx.doi.org/10.1093/bioinformatics/btp124
SpliceAid: a database of experimental RNA target motifs bound by splicing proteins in humans

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Summary: The correct post-transcriptional RNA processing is finely regulated by RNA-binding proteins. Unfortunately, there is little experimental information on target RNA sequences of RNA-binding proteins and moreover such experimentally derived target sequences are annotated in a compact form by the score matrices that overestimate the number of possible recognized sequences. We carried out an exhaustive hand curated literature search to create a database, SpliceAid, collecting all the experimentally assessed target RNA sequences that are bound by splicing proteins in humans. We built a web resource, database driven, to easy query SpliceAid and give back the results by an accurate and dynamic graphic representation.

Availability: SpliceAid database is freely accessible at http://www.introni.it/splicing.html

Contact: f.piva@univpm.it

Journal Article.  2013 words. 

Subjects: Bioinformatics and Computational Biology

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