Journal Article

<i>In silico</i> analysis of promoter regions from cold-induced genes in rice (<i>Oryza sativa</i> L.) and <i>Arabidopsis thaliana</i> reveals the importance of combinatorial control

Angelica Lindlöf, Marcus Bräutigam, Aakash Chawade, Olof Olsson and Björn Olsson

in Bioinformatics

Volume 25, issue 11, pages 1345-1348
Published in print June 2009 | ISSN: 1367-4803
Published online March 2009 | e-ISSN: 1460-2059 | DOI: http://dx.doi.org/10.1093/bioinformatics/btp172

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Motivation:Cold acclimation involves a number of different cellular processes that together increase the freezing tolerance of an organism. The DREB1/CBFs are transcription factors (TFs) that are prominent in the regulation of cold responses in Arabidopsis thaliana, rice and many other crops. We investigated if the expression of DREB1/CBFs and co-expressed genes relies on combinatorial control by several TFs. Our results support this notion and indicate that methods for studying the regulation of complex cellular processes should include identification of combinations of motifs, in addition to searching for individual overrepresented binding sites.

Contact:angelica.lindlof@his.se

Supplementary information:Supplementary data are available at Bioinformatics online.

Journal Article.  3167 words.  Illustrated.

Subjects: Bioinformatics and Computational Biology

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