Journal Article

LS-SNP/PDB: annotated non-synonymous SNPs mapped to Protein Data Bank structures

Michael Ryan, Mark Diekhans, Stephanie Lien, Yun Liu and Rachel Karchin

in Bioinformatics

Volume 25, issue 11, pages 1431-1432
Published in print June 2009 | ISSN: 1367-4803
Published online April 2009 | e-ISSN: 1460-2059 | DOI: http://dx.doi.org/10.1093/bioinformatics/btp242
LS-SNP/PDB: annotated non-synonymous SNPs mapped to Protein Data Bank structures

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Summary: LS-SNP/PDB is a new WWW resource for genome-wide annotation of human non-synonymous (amino acid changing) SNPs. It serves high-quality protein graphics rendered with UCSF Chimera molecular visualization software. The system is kept up-to-date by an automated, high-throughput build pipeline that systematically maps human nsSNPs onto Protein Data Bank structures and annotates several biologically relevant features.

Availability: LS-SNP/PDB is available at http://ls-snp.icm.jhu.edu/ls-snp-pdb and via links from protein data bank (PDB) biology and chemistry tabs, UCSC Genome Browser Gene Details and SNP Details pages and PharmGKB Gene Variants Downloads/Cross-References pages.

Contact: karchin@jhu.edu

Supplementary Information: Supplementary data are available at Bioinformatics online.

Journal Article.  1151 words.  Illustrated.

Subjects: Bioinformatics and Computational Biology

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