Journal Article

ProtVirDB: a database of protozoan virulent proteins

Jayashree Ramana and Dinesh Gupta

in Bioinformatics

Volume 25, issue 12, pages 1568-1569
Published in print June 2009 | ISSN: 1367-4803
Published online April 2009 | e-ISSN: 1460-2059 | DOI:
ProtVirDB: a database of protozoan virulent proteins

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Summary: ProtVirDB is a comprehensive and user-friendly web-based knowledgebase of virulent proteins belonging to protozoan species. The database will facilitate research and provide an integrated platform for comparative studies of virulent proteins in different parasitic protozoans and organize them under a unifying classification schema with functional categories. Remarkably, one-third of the protein sequences in the database showed presence of either mono- or hetero-repeats, or both concomitantly—hence reiterating the importance of repeats in parasite virulence mechanisms. A number of useful bioinformatics tools including BLAST and tools for phylogenetic analysis are integrated with the database. With the rapidly burgeoning interest in the pathogenesis mechanisms of protozoans and ongoing genome sequencing projects, we anticipate that the database will be a useful tool for the research community.



Supplementary information: Supplementary data are available at Bioinformatics online

Journal Article.  1289 words.  Illustrated.

Subjects: Bioinformatics and Computational Biology

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