Journal Article

MetaTISA: Metagenomic Translation Initiation Site Annotator for improving gene start prediction

Gang-Qing Hu, Jiang-Tao Guo, Yong-Chu Liu and Huaiqiu Zhu

in Bioinformatics

Volume 25, issue 14, pages 1843-1845
Published in print July 2009 | ISSN: 1367-4803
Published online April 2009 | e-ISSN: 1460-2059 | DOI: http://dx.doi.org/10.1093/bioinformatics/btp272
MetaTISA: Metagenomic Translation Initiation Site Annotator for improving gene start prediction

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Summary: We proposed a tool named MetaTISA with an aim to improve TIS prediction of current gene-finders for metagenomes. The method employs a two-step strategy to predict translation initiation sites (TISs) by first clustering metagenomic fragments into phylogenetic groups and then predicting TISs independently for each group in an unsupervised manner. As evaluated on experimentally verified TISs, MetaTISA greatly improves the accuracies of TIS prediction of current gene-finders.

Availability: The C++ source code is freely available under the GNU GPL license via http://mech.ctb.pku.edu.cn/MetaTISA/.

Contact: hqzhu@pku.edu.cn

Supplementary information: Supplementary data are available at Bioinformatics online.

Journal Article.  2263 words. 

Subjects: Bioinformatics and Computational Biology

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